VALIDOGEN GmbH (vormals/formerly VTU Technology)

VALIDOGEN ist ein fuhrendes Forschungs- und Entwicklungsunternehmen fur die Proteinproduktion mit der Hefe Pichia pastoris. VALIDOGEN bietet Hochleistungstechnologien zur Entwicklung wirtschaftlich attraktiver Produktionsprozesse beispielsweise zur Herstellung von Biopharmazeutika und Enzymen. VALIDOGEN wird ein privates Unternehmen im Besitz der KonValue Gruppe.

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VALIDOGEN, a leading contract research and development company, offers the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein production known as UNLOCK PICHIA. VALIDOGEN develops high performance expression strains and economically viable protein production processes for the manufacture of biopharmaceuticals, enzymes and various other recombinant proteins and provides tailormade solutions for customers from different industry sectors – such as pharma, diagnostics, food & feed, chemical, agro and other industries. VALIDOGEN will be a private company and independent subsidiary of KonValue Group.

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VALIDOGEN to present at PEPTALK 2020

20 - 24 January, San Diego, CA 

 Iskandar Dib, VALIDOGEN's Head of Analytics & DSP and Roland Weis, VALIDOGEN's Head of Operations will be attending PEPTALK 2020.
Don't miss Iskandar's presentation:Boosting VHH Expression Using UNLOCK PICHIA
Wednesday, 22 January, 9.20 am - 9.50 am, "Effective Expression and Production of Recombinant Proteins" stream

 VHHs, single-domain antibodies derived from camelid species represent the third generation of antibodies and are currently developed for an increasing number of different applications.

Efficient production of VHHs is enabled by VALIDOGEN’s yield-enhancing protein production toolbox known as UNLOCK PICHIA comprising a broad diversity of molecular tools and expression strategies for Pichia. We demonstrate significant enhancement of VHH expression by a set of helper factors acting along the way from transcription to secretion.

Spotlight on high-yield VHH expression using UNLOCK PICHIA

VHHs, derived from camelid species, the so-called “third generation” of antibodies and also known as sdAbs or Nanobodies®, feature a number of intriguing characteristics that make them superior for many applications. Compared to mAbs and antibody fragments (Fab and scFv), VHHs exhibit equally high specificities and affinities in antigen binding and show further advantages due to their small size, high solubility, thermal stability, design flexibility & modularity, good tissue penetration in vivo, ease of genetic engineering and expression in microbial systems.

As a consequence, VHHs are currently developed for an increasing number of different applications ranging from medical use as APIs (first approval of a Nanobody® - Caplacizumab - in 2018) and in vivo imaging reagents to diagnostic and analytical applications for diverse industries.

VALIDOGEN presenting advanced protein production tools at RPP conference in Crete, April 24-27, 2019

Dr. Roland Weis, VALIDOGEN’s Head of Operations, will contribute to the ‘Recombinant protein production processes at industrial scale’ session of the upcoming RPP10 conference on Day 3 (11.20 - 11.40 a.m., April 26) with his presentation on ‘Productivity through diversity - a protein production toolbox to UNLOCK PICHIA’.

“Novel product classes and current trends in biopharma production ask for versatile and yet robust expression systems. Our answer is a yield-enhancing protein production toolbox, ‘UNLOCK PICHIA’, that enables fine-tuning of protein expression by its diversity of molecular tools and expression strategies for Pichia,” Roland Weis explained.

UNLOCK PICHIA - Productivity through diversity

VALIDOGEN to co-present with Boehringer Ingelheim at BPI International US West 2019, 11 - 14 March, Santa Clara, CA

Iskandar Dib, Principal Scientist Process Development & Analytics, VALIDOGEN GmbH
Stefan Krahulec, Senior Manager Technology & Innovation, Boehringer Ingelheim RCV GmbH & Co KG
 "Best practice model for collaborative end to end process development and manufacturing using P. pastoris"
Monday, 11 March, 3:30 - 4:00 pm
BPI's Pre-Conference Symposium on Microbial Manufacturing
This joint talk will illustrate how the versatile genetic toolbox UNLOCK PICHIA, VALIDOGEN’s established strain generation strategies and seamless process transfer between the two companies enable fast track development from gene to GMP. In a case study example, Iskandar and Stefan will discuss strain and process improvements made, process development for Phase I and successful transfer to GMP scale.
Iskandar and Stefan will also participate in the "Thought Leaders Discussion: Where Is, Microbial Production Going?" on March 11, 9:30 - 10:00 am.
Topics to be discussed will cover the role of microbial hosts in the bioproduction space, technologies and product advances that will change the market for microbial production and drive industry away from traditional CHO platforms as well as the development of microbial platform approaches.

Umfirmierung: Aus VTU Technology wird VALIDOGEN

VTU Technology GmbH, ein führender Anbieter exklusiver Technologien und Services für die Entwicklung von Hochleistungsprozessen zur Proteinproduktion mit der Hefe Pichia pastoris, firmiert im Zuge einer Neuorganisation der VTU Holding GmbH ab sofort unter dem Namen VALIDOGEN GmbH.

In den 10 Jahren seines Bestehens, hat sich das Unternehmen erfolgreich als weltweit führender Dienstleister im Bereich der Pichia Prozessentwicklung etabliert.


You need stable, robust and scalable processes for commercial manufacturing?

Are you looking for a process yielding consistent product quality?

Are you seeking to acquire process knowledge?

Pichia processes at VTU show extraordinarily high space-time yields and typical product concentrations of 10 - 20 g/l at raw product purities of 80 - 90 % in culture supernatant before downstream processing.

VTU's strain development program for yield & quality optimization

Apply VTU's entire protein production toolbox to increase product quality and enhance product yields through comprehensive production strain development

Do you need to maximize your yield to be competitive?

Are you seeking to improve product quality of your protein?

Are you in search of high performance expression strains efficiently expressing your protein suitable for commercial protein production?

Visit VTU Technology´s new website and discover VTU´s Pichia protein production toolbox

Competitive through diversity - boost protein yields & quality

Building on Pichia´s inherent potential, VTU established an exclusive yield-enhancing protein production toolbox, standing out due to its diversity of expression tools and expression strategies. We fine-tune the expression of your protein by unlocking and boosting Pichia´s potential for effective production of fully active, high quality proteins.


Discover the elements of VTU´s toolbox